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VisitLocation![]() Kirksville is located in the heart of Northern Missouri along US Highway 63. You can get to Kirksville easily from St. Louis, Kansas City or Columbia via 4-lane highways. Kirksville is a short drive north of US Highway 36 (where many famous Missouri Residents have lived). Kirksville is just north of the Amtrak Station in La Plata. Kirksville also has an airport. Two flights per day
arrive from St. Louis via Air Choice One.
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