Getting to Kirksville, Missouri

Kirksville is located in the heart of Northeast Missouri along US Highway 63. You can reach Kirksville easily from St. Louis, Kansas City, or Columbia, Missouri via 4-lane highways. Additionally, both a commercial airport and an Amtrak train station are located just minutes south of Kirksville.
See a map Welcome (Back) to Kirksville!

Highway Access

  • St Hwy 6
  • St Hwy 11
  • US Hwy 63

…and a short drive north of US Hwy 36

Nearest Large Cities

  • Columbia, MO: 88 miles
  • Des Moines, IA: 150 miles
  • Kansas City, MO: 156 miles
  • St. Louis, MO: 192 miles
  • Chicago, IL: 384 miles

See a map

For upcoming roadwork and weather related road conditions, see the Missouri Traveler Information Map.  The map is also available for smartphones by searching for MoDOT in the appropriate app store.

Cape Air Commercial Air Service / Kirksville Regional Airport

With a 6,000-foot hard surface runway, Kirksville Regional Airport (IRK) is a FAA Part 139 airport servicing commercial and private aircrafts.  Cape Air provides three daily flights to and from St. Louis Lambert International Airport. Purchase tickets at For information regarding non-commercial service, call 660-665-5020 or visit

See a map

Amtrak Train Service

An Amtrak train station is only 12 miles south of Kirksville, located in La Plata, Missouri. Two passenger trains, the eastbound and the westbound Southwest Chief, stop daily to board and drop off passengers. View current Southwest Chief Schedule.  Call 800-USA-RAIL or purchase tickets at See a map

Greyhound Bus Service

Greyhound provides daily bus service both northbound toward Ottumwa, IA and southbound toward Springfield, MO. The bus stop is located at 2214 N. Baltimore Street  at the Ayer Co #29.  Tickets must be purchased in advance either online at or via phone at 1-800-231-2222. (Tickets cannot be purchased at the bus stop.)


Kirk-Tran, Kirksville’s public transit service, offers a demand-response system (shuttle-type service) by which point-to-point rides are scheduled in advance by calling the dispatch center. Visit the City’s Kirk-Tran page to see route and fare information, or call 660-665-8404 to schedule a ride. The system operates from 6 a.m. to 6 p.m. Monday – Friday. See a map

Taxi and Limo Service

Wize Guyz Taxi 660-627-8117

D & D Cab 660-665-4181 (operates from 7:00 am – 8:00 pm)

Grand Luxury Limousine 660-342-2343

Good Guys Shuttle, LLC (event and group shuttle service) – 660-341-0746


Car Rental Service

Enterprise Rent-A-Car

2611 S. Franklin Street Kirksville, MO 660-665-3396 or 1-800-261-7331

Driving Directions

From Kansas City:

Take I-35 North. Exit to 36-East in Cameron. Exit to 63-North in Macon, and continue on 63-North to Kirksville. (Approximately a 3-hour drive from Kansas City International Airport.)

From St. Louis:

Take I-70-West. Exit to 63-North in Columbia, and continue on 63-North to Kirksville. (Approximately a 3.5-hour drive from St. Louis-Lambert Airport.) Alternatively, another route is to exit I-70/40 to 61-North to arrive Kirksville via Hannibal. From Hannibal, take 36-West to Macon and exit to 63-North to Kirksville.

EV Charging Station: Ayerco, 2214 N. Baltimore

Tesla Charging Station: Hampton Inn, 2604 N. Baltimore

Hike & Bike

Students at Truman State UniversityIf you are interested in exploring the City of Kirksville by foot or bike, check out these resources:

Kirksville Trail Map

This map shows the City of Kirksville with constructed trails highlighted in blue and city parks highlighted in green.

Thousand Hills Park Trails

There are four trails throughout the park, ranging from .20 to 10.5 miles in length. The longest, Thousand Hills Trail, connects to Rainbow Basin Trail Road / County Road 226 and Highway H on the southwest side of Kirksville.

Forest Lake Area Trail System (FLATS)

FLATS is a volunteer organization constructing bike and walking trails between Kirksville and Thousand Hills State Park. The FLATS website also has useful information on the development of trails in Adair County.