Getting here

Kirksville is located in the heart of Northeast Missouri along US Highway 63. You can reach Kirksville easily from St. Louis, Kansas City, or Columbia, Missouri via 4-lane highways. Additionally, both a commercial airport and an Amtrak train station are located just minutes south of Kirksville.

Highway Access

  • St Hwy 6
  • St Hwy 11
  • US Hwy 63

…and a short drive north of US Hwy 36

Nearest Large Cities

  • Columbia, MO: 88 miles
  • Des Moines, IA: 150 miles
  • Kansas City, MO: 156 miles
  • St. Louis, MO: 192 miles
  • Chicago, IL: 384 miles

See a map

For upcoming roadwork and weather related road conditions, see the Missouri Traveler Information Map.  The map is also available

 for smartphones by searching for MoDOT in the appropriate app store.

Contour Airlines / Kirksville Regional Airport

With a 6,000-foot hard surface runway, Kirksville Regional Airport (IRK) is a FAA Part 139 airport servicing commercial and private

 aircrafts.  Contour Airlines provides daily flights to and from Chicago O'Hare International Airport. Purchase tickets at

For information regarding non-commercial service, call 660-665-5020 or visit the airport webpage.

See a map

Amtrak Train Service

An Amtrak train station is only 12 miles south of Kirksville, located in La Plata, Missouri. Two passenger trains, the eastbound and the

 westbound Southwest Chief, stop daily to board and drop off passengers. . The station opens at 8:30 am until train time and then opens again at 6:30 pm.

View current Southwest Chief Schedule.

Call 800-USA-RAIL or purchase tickets at

See a map


Kirk-Tran uses a demand-response system where point-to-point riders are scheduled in advance by calling the dispatch center. This system operates Monday through Friday, from 6:00 am to 6:00 pm. Call 1.800.654.6287 to schedule a ride. Fare - $3.00 per one-way trip anywhere within Kirksville city limits; $4.00 per one-way trip outside of Kirksville city limits within a 15-mile radius of Downtown Kirksville. Children under 12 years of age, accompanied by a parent or guardian, ride free of charge.

Visit the City’s Kirk-Tran page to see route and fare information

The system operates from 6 a.m. to 6 p.m. Monday – Friday.

See a map

Taxi and Limo Service

Wize Guys Taxi 


Grand Luxury Limousine


Good Guys Shuttle, LLC

Event and group shuttle service


Car Rental Service

Enterprise Rent-A-Car

2611 S. Franklin Street Kirksville, MO 63501

660-665-3396 or 1-800-261-7331

Driving Directions

From Kansas City:

Take I-35 North

Exit to 36-East in Cameron

Exit to 63-North in Macon, and continue on 63-North to Kirksville

(Approximately a 3-hour drive from Kansas City International Airport.)

From St. Louis:

Take I-70-West

Exit to 63-North in Columbia, and continue on 63-North to Kirksville

(Approximately a 3.5-hour drive from St. Louis-Lambert Airport.)

Alternatively, another route is to exit I-70/40 to 61-North to arrive Kirksville via Hannibal.

From Hannibal, take 36-West to Macon and exit to 63-North to Kirksville.

EV Charging Station: Ayerco, 2214 N. Baltimore

Tesla Charging Station: Hampton Inn, 2604 N. Baltimore

Hike & Bike

If you are interested in exploring the City of Kirksville by foot or bike, check out these resources:

Kirksville Trail Map

This map shows the City of Kirksville with constructed trails highlighted in blue and city parks highlighted in green.

Thousand Hills Park Trails

There are four trails throughout the park, ranging from .20 to 10.5 miles in length. The longest, Thousand Hills Trail, connects to Rainbow Basin Trail Road / County Road 226 and Highway H on the southwest side of Kirksville.

Forest Lake Area Trail System (FLATS)

FLATS is a volunteer organization constructing bike and walking trails between Kirksville and Thousand Hills State Park. The FLATS website also has useful information on the development of trails in Adair County.

Photograph of people walking and biking along a paved path